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Also see: ATP Regulates Cell Water Lactate Paradox: High Altitude and Exercise Trauma & Resuscitation: Toxicity of Lactated Ringer’s Solution Sodium Deficiency and Stress I have written previously about several dramatically effective treatments for shock that were developed in the last fifty years–for example intravenous ATP, concentrated solutions of sodium chloride or glucose, and the [...]
J Exp Med. 1962 June 1; 115(6): 1149–1160. THE FECAL FLORA OF VARIOUS STRAINS OF MICE. ITS BEARING ON THEIR SUSCEPTIBILITY TO ENDOTOXIN Russell W. Schaedler and René J. Dubos Adult mice from seven different colonies were studied with regard to (a) the numbers and types of bacteria that could be cultivated from their stools; [...]
In adults, prostaglandins are known to be involved in many of the harmful effects of inflammation. They are formed from the polyunsaturated fats, linoleic acid and arachidonic acid, which we are unable to synthesize ourselves, so the adult’s exposure to the prostaglandins is influenced by diet. -Ray Peat, PhD Adv Shock Res. 1981;6:83-91. Implications for [...]
Hypoglycemia (which can result from any respiratory defect) can produce malfunction of any tissue, but brain dysfunction and immune dysfunction are very common effects. Adamkiewicz has shown that allergic reactions to a given substance will decrease from 100 percent to zero, when the blood glucose increases from, for example, 50 mg. to 150 mg. or [...]
Since Selye’s work, it has been known that estrogen creates the same conditions as occur in the shock phase of the stress reaction. (And shock, in a potential vicious circle, can increase the level of estrogen.) -Ray Peat, PhD Circ Shock. 1994 Aug;43(4):171-8. Sex steroid hormones in circulatory shock, sepsis syndrome, and septic shock. Fourrier [...]
Diabetes Care. 2007 Jun;30(6):1406-11. Epub 2007 Mar 23. Orange juice or fructose intake does not induce oxidative and inflammatory response. Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P. OBJECTIVE: We have previously shown that 300 kcal from glucose intake induces a significant increase in reactive oxygen species (ROS) generation and nuclear [...]
Adv Shock Res. 1981;6:93-105. Essential fatty acid deficient rats: a new model for evaluating arachidonate metabolism in shock. Cook JA, Wise WC, Knapp DR, Halushka PV. Essential fatty acid deficient (EFAD) rats are significantly more resistant to the lethal effects of S. enteritidis endotoxin (20 mg/kg, IV) than normal control rats. Compared to endotoxin-treated normal [...]
by Ray Peat, PhD A review of the use of estrogens reported in J.A.M.A. (only up to 1987) found nearly 200 different “indications for its use. (Palmlund, 1996.) Using the conservative language of that journal, such use could be said to constitute wildly irresponsible “empirical” medical practice. More appropriate language could be used. Pollution of [...]