Am J Clin Nutr. 2000 Aug;72(2 Suppl):573S-8S. Serotonin and central nervous system fatigue: nutritional considerations. Davis JM, Alderson NL, Welsh RS. Fatigue from voluntary muscular effort is a complex phenomenon involving the central nervous system (CNS) and muscle. An understanding of the mechanisms within muscle that cause fatigue has led to the development of nutritional [...]