Energy depletion itself is an excitatory state, that calls for increased fuel and oxygen. But when cells are exposed to PUFA, their ability to use glucose is blocked, increasing their exposure to the fats. Saturated fats activate the pyruvate dehydrogenase enzyme that is essential for the efficient use of glucose, while PUFA block it. -Ray Peat, [...]
Also see: PUFA, Fish Oil, and Alzheimers Biochemistry. 1998 Jan 13;37(2):552-7. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Humphries KM, Yoo Y, Szweda LI. During the progression of certain degenerative conditions, including myocardial ischemia-reperfusion injury, mitochondria are a source of increased free-radical generation and exhibit declines in respiratory function(s). It has therefore been suggested that [...]
