Browsing articles in "General"
J Endocrinol September 1, 1974 62 439-449 SHORT-TERM EFFECTS OF OESTRADIOL BENZOATE IN NORMAL, HYPOPHYSECTOMIZED AND ALLOXAN-DIABETIC MALE RATS M. N. GOODMAN and R. L. HAZELWOOD Studies were undertaken to determine the effects and possible mode of action of 17β-oestradiol benzoate (OEB) in alloxan-diabetic male rats. Adlibitum or pair-fed normal, diabetic, and hypophysectomized rats received [...]
J Endocrinol September 1, 1974 62 439-449 SHORT-TERM EFFECTS OF OESTRADIOL BENZOATE IN NORMAL, HYPOPHYSECTOMIZED AND ALLOXAN-DIABETIC MALE RATS M. N. GOODMAN and R. L. HAZELWOOD Studies were undertaken to determine the effects and possible mode of action of 17β-oestradiol benzoate (OEB) in alloxan-diabetic male rats. Adlibitum or pair-fed normal, diabetic, and hypophysectomized rats received [...]
It’s impossible to avoid dietary fats unless you’re eating a laboratory prepared diet. We don’t require any fats in the diet realistically though as the body will manufacture its own fats from glucose and they will be saturated or omega-9 Mead Acid. Healthy babies are born with an “EFA deficiency” shown by the presence of [...]
Broda Barnes, more than 60 years ago, summed up the major effects of hypothyroidism on health very neatly when he pointed out that if hypothyroid people don’t die young from infectious diseases, such as tuberculosis, they die a little later from cancer or heart disease. -Ray Peat, PhD A low metabolism affects ALL bodily systems. [...]
Although we commonly think of the ovaries as the main source of estrogen, the enzyme which makes it can be found in all parts of the body. Surprisingly, in rhesus monkeys, aromatase in the arms accounts for a very large part of estrogen production. Fat and the skin are major sources of estrogen, especially in [...]
http://en.wikipedia.org/wiki/File:Testosterone_estradiol_conversion.png J Steroid Biochem. 1986 May;24(5):1033-9. Aromatase activity and concentrations of cortisol, progesterone and testosterone in breast and abdominal adipose tissue. Newton CJ, Samuel DL, James VH. Aromatase activity and concentrations of cortisol, progesterone and testosterone were measured in samples of breast and abdominal adipose tissue obtained from both pre- and postmenopausal subjects. Enzyme activity [...]
If our purpose is to delay the menopausal rise of the gonadotrophins, then it is interesting that lipid peroxidation of polyunsaturated fatty acids (which increases with age) can be intimately involved in loss of progesterone forming ability by human steroidogenic tissues. -Ray Peat, PhD http://en.wikipedia.org/wiki/File:Biosynthesis_progesterone.png J Steroid Biochem Mol Biol. 1992 Aug;42(7):729-36. The influence of [...]
Journal of Nutritional & Environmental Medicine, Volume 11, Number 3, 1 September 2001 , pp. 159-166(8) Thyroid Insufficiency. Is Thyroxine the Only Valuable Drug? Baisier, W.V.; Hertoghe, J.; Eeckhaut, W. Purpose: To evaluate the efficacy of a drug containing both liothyronine and thyroxine (T3 + T4) in hypothyroid patients who were treated, but not cured, [...]
Some energy sources, medium chain fatty acids (MCFA or MCT) from saturated fats, are even more ideal than glucose. These fatty acids do not require bile to be broken down and do not require the carnitine transport system to enter the mitochondria. They go from the gut to the liver to be metabolized as quick [...]
In fact, the addition of thyroxine to brain slices suppressed their respiration by 6% during the experiment. Since most T3 is produced from T4 in the liver, not in the brain, I think that experiment had great significance, despite the ignorant interpretation of the author. An excess of thyroxine, in a tissue that doesn’t convert [...]
