Also see:
Estrogen, Serotonin, and Aggression
Fermentable Carbohydrates, Anxiety, Aggression
Anti Serotonin, Pro Libido
Gelatin > Whey
Thyroid peroxidase activity is inhibited by amino acids
Whey, Tryptophan, & Serotonin
Tryptophan, Fatigue, Training, and Performance
Carbohydrate Lowers Free Tryptophan
Protective Glycine
Intestinal Serotonin and Bone Loss
Hypothyroidism and Serotonin
Estrogen Increases Serotonin
Whey, Tryptophan, & Serotonin
Tryptophan, Sleep, and Depression
Intestinal Serotonin and Bone Loss
Linoleic Acid and Serotonin’s Role in Migraine
Gelatin, Glycine, and Metabolism
Serotonin and Melatonin Lower Progesterone
The Serotonin Irritation Syndrome (SIS)
Plant Toxins in Response to Stress
Toxic Plant Estrogens
Dietary Fiber, Bowel Health, and Cancer
Fermentable Carbohydrates, Anxiety, Aggression
Bowel Toxins Accelerate Aging
“Plantains are very proinflammatory, with a high serotonin content; commercial orange juice, especially if it doesn’t separate when standing for a few hours, can produce bowel irritation by supporting bacterial growth because of the suspended modified fiber, and watermelons that aren’t perfectly ripe have enough starch to cause problems, though very ripe watermelon is safe.” -Ray Peat, PhD
Am J Clin Nutr. 1985 Oct;42(4):639-43.
Serotonin content of foods: effect on urinary excretion of 5-hydroxyindoleacetic acid.
Feldman JM, Lee EM.
Using a highly specific radioenzymatic assay we determined the serotonin concentration in 80 types of foods. The following fruits had a high serotonin concentration (mean +/- SEM) expressed in micrograms/g weight: plantain 30.3 +/- 7.5; pineapple 17.0 +/- 5.1; banana 15.0 +/- 2.4; Kiwi fruit 5.8 +/- 0.9; plums 4.7 +/- 0.8; and tomatoes 3.2 +/- 0.6. Only nuts in the walnut or hickory family had a high serotonin concentration expressed in micrograms/g weight; butternuts 398 +/- 90; black walnuts 304 +/- 46; English walnuts 87 +/- 20; shagbark hickory nuts 143 +/- 23; mockernut hickory nuts 67 +/- 13; pecans 29 +/- 4; and sweet pignuts 25 +/- 8. Ingestion of these fruits and nuts resulted in an increase in urinary 5-hydroxyindoleacetic acid excretion with no change in platelet serotonin concentration. The above foods should not be eaten while a urine is being collected for 5-hydroxyindoleacetic acid analysis.
J Chromatogr A. 2011 Jun 24;1218(25):3890-9. doi: 10.1016/j.chroma.2011.04.049. Epub 2011 Apr 27.
Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry.
Huang X, Mazza G.
An analytical method was developed for the simultaneous quantification of serotonin, melatonin, trans- and cis-piceid, and trans- and cis-resveratrol using reversed-phase high performance liquid chromatography coupled to mass spectrometry (HPLC-MS) with electrospray ionization (ESI) in both positive and negative ionization modes. HPLC optimal analytical separation was achieved using a mixture of acetonitrile and water with 0.1% formic acid as the mobile phase in linear gradient elution. The mass spectrometry parameters were optimized for reliable quantification and the enhanced selectivity and sensitivity selected reaction monitoring mode (SRM) was applied. For extraction, the direct analysis of initial methanol extracts was compared with further ethyl acetate extraction. In order to demonstrate the applicability of this analytical method, serotonin, melatonin, trans- and cis-piceid, and trans- and cis-resveratrol from 24 kinds of commonly consumed fruits were quantified. The highest serotonin content was found in plantain, while orange bell peppers had the highest melatonin content. Grape samples possessed higher trans- and cis-piceid, and trans- and cis-resveratrol contents than the other fruits. The results indicate that the combination of HPLC-MS detection and simple sample preparation allows the rapid and accurate quantification of serotonin, melatonin, trans- and cis-piceid, and trans- and cis-resveratrol in fruits.
J Pharm Pharmacol. 1960 Jun;12:360-4.
A note on the presence of noradrenaline and 5-hydroxytryptamine in plantain (Musa sapientum, var. paradisiaca).
FOY JM, PARRATT JR.
Noradrenaline, 5-hydroxytryptamine and dopamine are present in the fruit of Musa sapientum, var. paradisiaca (Plantain), which forms a staple food of many inhabitants of West Africa. The amounts of 5-hydroxytryptamine and noradrenaline are highest when the fruit is ripe. An estimated daily intake of 10 mg. of 5-hydroxytryptamine by West Africans has little apparent effect on the normal functioning of the intestinal tract.
J Assoc Off Anal Chem. 1980 Jan;63(1):19-21.
Spectrofluorometric determination and thin layer chromatographic identification of serotonin in foods.
García-Moreno C, Nogales-Alarcon A, Gómez-cerro A, Marine-Font A.
A method is described for determining serotonin in foods, based on alkaline butanol-sand column elution followed by spectrofluorometric and spectrofluorometric determination with thin layer chromatographic confirmation. The method has been applied to fresh bananas, banana-based baby food, and fresh and canned tomatoes. The average recovery was 91%. The amounts of serotonin found were 10–30 ppm in bananas, 0.1–1.9 ppm in banana-based baby foods, 4.4–5.6 ppm in fresh tomatoes, and 2.8–5.6 ppm in canned tomatoes.
J Assoc Off Anal Chem. 1983 Jan;66(1):115-7.
Improved method for determination and identification of serotonin in foods.
García-Moreno C, Rivas-Gonzalo JC, Peña-Egido MJ, Mariné-Font A.
A previously described method to identify and quantitate serotonin in foods has been improved. The extraction and separation of serotonin from interfering substances has been improved, and the scope of material to which the method may be applied has been widened. The relative standard deviation (RSD) for repeated determinations of serotonin in canned fried tomato purée and the average recovery of serotonin added to the same sample was 6.25 and 89.9%, respectively. The method showed the presence of serotonin in apricots, cherries, and peaches.
