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Autoimmunity, Thyroiditis, and Intestinal Flora

Also see:
Ray Peat, PhD on the Benefits of the Raw Carrot
How does estrogen enhance endotoxin toxicity? Let me count the ways.
Autoimmune Disease and Estrogen Connection
The effect of raw carrot on serum lipids and colon function
Protective Bamboo Shoots
Endotoxin: Poisoning from the Inside Out
Hypothyroidism, Intestinal Bacterial Overgrowth, & Lactose Intolerance

“Endotoxin or other materials absorbed from intestinal bacteria contributes to a variety of autoimmune problems, including thyroiditis (Penhale and Young, 1988). Combining indigestible fiber, such as raw carrot, with mild germicides, such as vinegar and coconut oil, can improve the hormonal environment, while reducing the immunological burden.” -Ray Peat, PhD from “Thyroiditis. Some confusions and causes of “autoimmune disease””

Clin Exp Immunol. 1988 May;72(2):288-92.
The influence of the normal microbial flora on the susceptibility of rats to experimental autoimmune thyroiditis.
Penhale WJ, Young PR.
Female PVG/c strain rats maintained under specific pathogen-free conditions until weaning were found to be significantly less susceptible to the induction of autoimmune thyroiditis by thymectomy and irradiation than conventionally reared rats of the same strain. Other SPF-derived strains had a similarly low susceptibility, thus pointing to an important external factor influencing the induction of autoimmunity by this procedure. It was found that the oral administration of antibiotics followed by fresh, homogenized, intestinal contents obtained from conventionally reared rats to newly weaned SPF PVG/c rats significantly augmented their autoimmune susceptibility. The offspring of female SPF rats which had been treated in late pregnancy with oral antibiotics and conventional intestinal contents were similarly more susceptible than the offspring of non-treated counterparts. It is proposed that the composition of the normal gastrointestinal flora of conventionally reared rats profoundly influences susceptibility to the induction of autoimmune thyroiditis in this particular experimental model, possibly by antigenic cross-reactivity with thyroid tissue.

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