Browsing articles from "March, 2012"

Linoleic Acid and Serotonin’s Role in Migraine

Mar 23, 2012   //   by Team FPS   //   essential fatty acids, General, headache, linoleic acid, migraine, omega 6, prostaglandin, PUFA, serotonin, stress, tryptophan  //  Comments Off on Linoleic Acid and Serotonin’s Role in Migraine
Res Clin Stud Headache. 1978;6:110-6. Role of individual free fatty acids in migraine. Anthony M. Total plasma free fatty acids, platelet serotonin content and plasma stearic, palmitic, oleic and linoleic acids were estimated in 10 migraine patients before, during and after a migraine attack. Total and individual plasma free fatty acid levels rose and platelet [...]

PUFA Breakdown Products Depress Mitochondrial Respiration

Mar 22, 2012   //   by Team FPS   //   brain, energy, free radical, General, HNE, lipid peroxide, metabolism, mitochondria, oxidative stress, PUFA, Ray Peat  //  Comments Off on PUFA Breakdown Products Depress Mitochondrial Respiration
Also see: PUFA, Fish Oil, and Alzheimers Biochemistry. 1998 Jan 13;37(2):552-7. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Humphries KM, Yoo Y, Szweda LI. During the progression of certain degenerative conditions, including myocardial ischemia-reperfusion injury, mitochondria are a source of increased free-radical generation and exhibit declines in respiratory function(s). It has therefore been suggested that [...]

Plasma Estrogen Does Not Reflect Tissue Concentration of Estrogen

Mar 21, 2012   //   by Team FPS   //   General  //  Comments Off on Plasma Estrogen Does Not Reflect Tissue Concentration of Estrogen
J Natl Cancer Inst Monogr. 2000;(27):95-112. Tissue-specific synthesis and oxidative metabolism of estrogens. Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L. Estrogen exposure represents the major known risk factor for development of breast cancer in women and [...]

Serum Estrogen Does Not Reflect Tissue Concentration of Estrogen

Mar 21, 2012   //   by Team FPS   //   General  //  Comments Off on Serum Estrogen Does Not Reflect Tissue Concentration of Estrogen
J Natl Cancer Inst Monogr. 2000;(27):95-112. Tissue-specific synthesis and oxidative metabolism of estrogens. Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L. Estrogen exposure represents the major known risk factor for development of breast cancer in women and [...]

Estrogen Levels Increase with Age

Mar 21, 2012   //   by Team FPS   //   aging, dominance, estrogen, General, menopause, metabolism, perimenopause, thyroid  //  Comments Off on Estrogen Levels Increase with Age
Also see: Fat Tissue and Aging – Increased Estrogen J Gerontol. 1978 Mar;33(2):191-6. Circulating plasma levels of pregnenolone, progesterone, estrogen, luteinizing hormone, and follicle stimulating hormone in young and aged C57BL/6 mice during various stages of pregnancy. Parkening TA, Lau IF, Saksena SK, Chang MC. Young (3-5 mo of age) and senescent (12-15 mo of [...]

Ray Peat, PhD on Therapeutic Effects of Niacinamide

Mar 21, 2012   //   by Team FPS   //   General, Niacinamide, protective nutrition, Ray Peat, thyroid  //  Comments Off on Ray Peat, PhD on Therapeutic Effects of Niacinamide
“Niacinamide, used in moderate doses, can safely help to restrain the excessive production of free fatty acids, and also helps to limit the wasteful conversion of glucose into fat.” “Niacinamide, one of the B vitamins, provides energy to the mitochondrial system. Under stress and strong excitation, cells waste niacinamide NADH, but niacinamide itself has a [...]

Removal of the Pituitary – Extends Lifespan, Slows Hardening of Collagen

Mar 21, 2012   //   by Team FPS   //   aging, collagen, General, life span, longevity, pituitary  //  Comments Off on Removal of the Pituitary – Extends Lifespan, Slows Hardening of Collagen
On the level of the whole organism, stress causes overactivity of the pituitary, and removal of the pituitary extends life, and retards the hardening of the extracellular connective material (Everitt, et al., 1983). -Ray Peat, PhD Mech Ageing Dev. 1983 Jul-Aug;22(3-4):233-51. The anti-aging action of hypophysectomy in hypothalamic obese rats: effects on collagen aging, age-associated [...]

Thyroid peroxidase activity is inhibited by amino acids

Mar 21, 2012   //   by Team FPS   //   cysteine, General, metabolism, methionine, Ray Peat, thyroid, tryptophan  //  Comments Off on Thyroid peroxidase activity is inhibited by amino acids
Muscle catabolism also releases a large amount of cysteine, and cysteine, methionine, and tryptophan suppress thyroid function (Carvalho, et al., 2000). -Ray Peat, PhD Muscle protein is very rich in tryptophan and cysteine, and these amino acids suppress the thyroid gland’s function, and are potentially toxic to nerves, especially in the presence of cortisol and [...]

Oral Contraceptives and Risk of Death from Myocardial Infarction

Mar 20, 2012   //   by Team FPS   //   birth control, contraception, estrogen, General, heart disease, Myocardial Infarction  //  Comments Off on Oral Contraceptives and Risk of Death from Myocardial Infarction
British Medical_Journal, 1975, 2, 245-248 Oral Contraceptives and Death from Myocardial Infarction J. I. MANN, W. H. W. INMAN We investigated 219 deaths from myocardial infarction in women under the age of 50. Their histories were compared with those of living age-matched controls selected from the same general practices. The frequency of use of oral [...]

High Estrogen and Heart Disease in Men

Mar 20, 2012   //   by Team FPS   //   atherosclerosis, estrogen, General, heart disease, men, metabolism, Myocardial Infarction, thyroid  //  Comments Off on High Estrogen and Heart Disease in Men
Arteriosclerosis. 1986 Jul-Aug;6(4):418-21. Sex hormone levels in young Indian patients with myocardial infarction. Sewdarsen M, Jialal I, Vythilingum S, Desai R. The finding of abnormal levels of sex hormones in men with coronary artery disease has led to the hypothesis that alterations in sex hormones may represent an important risk factor for myocardial infarction. In [...]
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